Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions. The characterizations of the optimal formulation were...

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Bibliographic Details
Main Authors: Nannan Gao, Mengran Guo, Qiang Fu, Zhonggui He
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Hot melt extrusion
Solid dispersion
Oleanolic acid
Dissolution rate
Oral bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300630

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http://www.sciencedirect.com/science/article/pii/S1818087616300630

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