Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction

Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction

Abstract Abnormal granulosa cell (GC) death contributes to cyclophosphamide (CTX) induced primary ovarian insufficiency (POI). To investigate the contribution of GCs to POI, gene profiles of GCs exposed to CTX were assessed using RNA-Seq and bioinformatics analysis. The results showed the differenti...

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Bibliographic Details
Main Authors: Hui Chen, Ping Nie, Jingling Li, Yongqi Wu, Bo Yao, Yabing Yang, Gendie E. Lash, Ping Li
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Ovarian Research
Subjects:
Granulosa cell
Ferroptosis
Cyclophosphamide
Heme oxygenase 1
Mitochondria
Online Access:https://doi.org/10.1186/s13048-024-01434-z

Internet

https://doi.org/10.1186/s13048-024-01434-z

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