Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression. We investigated whether human embryonic stem cell...

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Bibliographic Details
Main Authors: Nickesha C. Anderson, Meghan A. Van Zandt, Swechhya Shrestha, Daniel B. Lawrence, Jyoti Gupta, Christopher Y. Chen, Felicia A. Harrsch, Trinithas Boyi, Carolyn E. Dundes, Gloster Aaron, Janice R. Naegele, Laura Grabel
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118302484

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http://www.sciencedirect.com/science/article/pii/S1873506118302484

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