Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction.

Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction.

Levels of bile acid metabolic enzymes and membrane transporters have been reported to change in cholestasis. These alterations (e.g. CYP7A1 repression and MRP4 induction) are thought to be adaptive responses that attenuate cholestatic liver injury. However, the molecular mechanisms of these adaptive...

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Bibliographic Details
Main Authors: Jin Chai, Xinchan Feng, Liangjun Zhang, Sheng Chen, Ying Cheng, Xiaochong He, Yingxue Yang, Yu He, Huaizhi Wang, Rongquan Wang, Wensheng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370735?pdf=render

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http://europepmc.org/articles/PMC4370735?pdf=render

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