Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells

Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a primary immunodeficiency disease caused by mutations in exon 45 of the DOCK8 gene. The clinical signs primarily consist of increased serum IgE levels, eczema, repeated skin infections, allergies, and upper respiratory tract infections. Usin...

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Bibliographic Details
Main Authors: Panpan Jiang, Siyu Zhao, Xiaoyu Li, Shiyan Hu, Shuhan Chen, Yinming Liang, Lichen Zhang, Liaoxun Lu, Guofeng Fang, Lu Yang, Yanmei Huang, Heather Miller, Fei Guan, Jiahui Lei, Chaohong Liu
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:MedComm
Subjects:
differentiation
DOCK8
glycolytic
T cell
Online Access:https://doi.org/10.1002/mco2.747

Internet

https://doi.org/10.1002/mco2.747

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