Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine

Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine

Abstract Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and booster effects of that vaccine over a period representing a mouse’s lifespan. The vaccine remained effective for over one year, and booster v...

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Bibliographic Details
Main Authors: Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Keishi Miyata, Daisuke Torigoe, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00770-3

Internet

https://doi.org/10.1038/s41541-023-00770-3

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