Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury

Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury

Acetaminophen (APAP) is the major cause of drug-induced liver injury, with limited treatment options. APAP overdose invokes excessive oxidative stress that triggers mitochondria-to-nucleus retrograde pathways, contributing to APAP-induced liver injury (AILI). Mesenchymal stem cell therapy is a promi...

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Bibliographic Details
Main Authors: Yelei Cen, Guohua Lou, Jinjin Qi, Minwei Li, Min Zheng, Yanning Liu
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
mesenchymal stem cell
APAP-induced liver injury
mitochondria retrograde
ROS
DNA damage
Online Access:https://www.mdpi.com/2076-3921/12/1/158

Internet

https://www.mdpi.com/2076-3921/12/1/158

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