A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease

A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease

Summary: Dysregulated iron or Ca2+ homeostasis has been reported in Parkinson’s disease (PD) models. Here, we discover a connection between these two metals at the mitochondria. Elevation of iron levels causes inward mitochondrial Ca2+ overflow, through an interaction of Fe2+ with mitochondrial calc...

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Bibliographic Details
Main Authors: Vinita Bharat, Aarooran S. Durairaj, Roeland Vanhauwaert, Li Li, Colin M. Muir, Sujyoti Chandra, Chulhwan S. Kwak, Yann Le Guen, Pawan Nandakishore, Chung-Han Hsieh, Stefano E. Rensi, Russ B. Altman, Michael D. Greicius, Liang Feng, Xinnan Wang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015565

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http://www.sciencedirect.com/science/article/pii/S2211124723015565

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