Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation. Metabolomic analyses demonstrated that tryptophan is differentially catabo...

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Bibliographic Details
Main Authors: Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Biological sciences
Human metabolism
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222005119

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http://www.sciencedirect.com/science/article/pii/S2589004222005119

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