The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular Magnesium Ions

The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular Magnesium Ions

Electrical synapses between neurons in the mammalian CNS are predominantly formed of the connexin36 (Cx36) gap junction (GJ) channel protein. Unique among GJs formed of a number of other members of the Cx gene family, Cx36 GJs possess a high sensitivity to intracellular Mg2+ that can robustly act to...

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Bibliographic Details
Main Authors: Tadas Kraujalis, Lukas Gudaitis, Lina Kraujaliene, Mindaugas Snipas, Nicolás Palacios-Prado, Vytas K. Verselis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Physiology
Subjects:
gap junction
connexin
intracellular Mg2+
ion permeability
electrophysiology
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.839223/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.839223/full

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