The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex

The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex

The formation of the mitotic checkpoint complex requires an intricate spatial coordination amongst the proteins Bub1, Mad1, Cdc20, and Mad2. Chen et al show that a structural flexibility in Mad1 plays an essential role in achieving this coordination.

Bibliographic Details
Main Authors: Chu Chen, Valentina Piano, Amal Alex, Simon J. Y. Han, Pim J. Huis in ’t Veld, Babhrubahan Roy, Daniel Fergle, Andrea Musacchio, Ajit P. Joglekar
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37235-z

Internet

https://doi.org/10.1038/s41467-023-37235-z

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