Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

BackgroundPorphyromonas gingivalis (Pg), the keystone pathogen in chronic periodontitis, is reported to initiate Alzheimer’s disease pathologies in preclinical studies. However, the specific mechanisms and signaling pathways acting on the brain still need to be further explored. Outer membrane vesic...

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Bibliographic Details
Main Authors: Ting Gong, Qi Chen, Hongchen Mao, Yao Zhang, Huan Ren, Mengmeng Xu, Hong Chen, Deqin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
porphyromonas gingivalis
outer membrane vesicles
inflammasome
neuroinflammation
Alzheimer’s disease
tau
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.925435/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.925435/full

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