Metabolic control analysis enables rational improvement of E. coli l-tryptophan producers but methylglyoxal formation limits glycerol-based production

Metabolic control analysis enables rational improvement of E. coli l-tryptophan producers but methylglyoxal formation limits glycerol-based production

Abstract Background Although efficient l-tryptophan production using engineered Escherichia coli is established from glucose, the use of alternative carbon sources is still very limited. Through the application of glycerol as an alternate, a more sustainable substrate (by-product of biodiesel prepar...

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Bibliographic Details
Main Authors: Kristin Schoppel, Natalia Trachtmann, Emil J. Korzin, Angelina Tzanavari, Georg A. Sprenger, Dirk Weuster-Botz
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Microbial Cell Factories
Subjects:
Metabolic control analysis
l-tryptophan
Methylglyoxal
Escherichia coli
Thermodynamics-based flux analysis
Glycerol
Online Access:https://doi.org/10.1186/s12934-022-01930-1

Internet

https://doi.org/10.1186/s12934-022-01930-1

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