Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats

c-Jun N-terminal kinase (JNK) is activated by various brain insults and is implicated in neuronal injury triggered by reperfusion-induced oxidative stress. Some JNK inhibitors demonstrated neuroprotective potential in various models, including cerebral ischemia/reperfusion injury. The objective of t...

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Bibliographic Details
Main Authors: Mark B. Plotnikov, Galina A. Chernysheva, Oleg I. Aliev, Vera I. Smol’iakova, Tatiana I. Fomina, Anton N. Osipenko, Victoria S. Rydchenko, Yana J. Anfinogenova, Andrei I. Khlebnikov, Igor A. Schepetkin, Dmitriy N. Atochin
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
c-Jun N-terminal kinase
JNK inhibitor
neuroprotection
model of global cerebral ischemia
antiradical activity
cerebral microcirculation
Online Access:https://www.mdpi.com/1420-3049/24/9/1722

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https://www.mdpi.com/1420-3049/24/9/1722

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