Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D<sub>3</sub> Derivatives with Structure–Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs

Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D<sub>3</sub> Derivatives with Structure–Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs

The active form of vitamin D<sub>3</sub>, 1α,25-dihydroxyvitamin D<sub>3</sub> [1,25(OH)<sub>2</sub>D<sub>3</sub>], is a major regulator of calcium homeostasis through activation of the vitamin D receptor (VDR). We have previously synthesized vitamin D...

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Bibliographic Details
Main Authors: Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
vitamin D
nuclear receptor
osteoblast differentiation
cell selectivity
Online Access:https://www.mdpi.com/2218-273X/13/7/1082

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https://www.mdpi.com/2218-273X/13/7/1082

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