Impact of Leucine and Magnesium Stearate on the Physicochemical Properties and Aerosolization Behavior of Wet Milled Inhalable Ibuprofen Microparticles for Developing Dry Powder Inhaler Formulation

Impact of Leucine and Magnesium Stearate on the Physicochemical Properties and Aerosolization Behavior of Wet Milled Inhalable Ibuprofen Microparticles for Developing Dry Powder Inhaler Formulation

This study investigated the development and characterization of leucine and magnesium stearate (MgSt) embedded wet milled inhalable ibuprofen (IBF) dry powder inhaler (DPI) formulations. IBF microparticles were prepared by a wet milling homogenization process and were characterized by SEM, FTIR, DSC...

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Bibliographic Details
Main Authors: Shahjabeen Sharif, Saiqa Muneer, Emad L. Izake, Nazrul Islam
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
ibuprofen wet milling homogenization
leucine
DPI formulations
aerosolization
Twin-Stage Impinger (TSI)
fine particle fraction
Online Access:https://www.mdpi.com/1999-4923/15/2/674

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https://www.mdpi.com/1999-4923/15/2/674

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