Interferon-γ induced by in vitro re-stimulation of CD4+ T-cells correlates with in vivo FMD vaccine induced protection of cattle against disease and persistent infection.

Interferon-γ induced by in vitro re-stimulation of CD4+ T-cells correlates with in vivo FMD vaccine induced protection of cattle against disease and persistent infection.

The immune defense against FMDV has been correlated to the antibody mediated component. However, there are occasions when some animals with high virus neutralising (VN) antibody are not protected following challenge and some with low neutralising antibody which do not succumb to disease. The importa...

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Bibliographic Details
Main Authors: Yooni Oh, Lucy Fleming, Bob Statham, Pip Hamblin, Paul Barnett, David J Paton, Jong-Hyeon Park, Yi Seok Joo, Satya Parida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3460943?pdf=render

Internet

http://europepmc.org/articles/PMC3460943?pdf=render

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