Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice

Background and aims: C–C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaques. Global knockout of Ccl2 reduces plaque formation and macrophage content in mice, but the importance of different plaque cell t...

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Bibliographic Details
Main Authors: Stine Gunnersen, Jeong Tangkjær Shim, Fan Liu, Uwe J.F. Tietge, Charlotte Brandt Sørensen, Jacob Fog Bentzon
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Atherosclerosis Plus
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667089523000512