4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing

4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing

4-methylumbelliferone (4MU) is a well-known hyaluronic acid synthesis inhibitor and an approved drug for the treatment of cholestasis. In animal models, 4MU decreases inflammation, reduces fibrosis, and lowers body weight, serum cholesterol, and insulin resistance. It also inhibits tumor progression...

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Bibliographic Details
Main Authors: Alexandra A. Tsitrina, Noreen Halimani, Irina N. Andreichenko, Marat Sabirov, Mikhail Nesterchuk, Nataliya O. Dashenkova, Roman Romanov, Elena V. Bulgakova, Arsen Mikaelyan, Yuri Kotelevtsev
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
4-methylumbelliferone
nuclear receptors
lipid metabolism
carbohydrate metabolism
RNA-Seq
Online Access:https://www.mdpi.com/1422-0067/24/3/2129

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https://www.mdpi.com/1422-0067/24/3/2129

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