The Transferrin Receptor-Directed CAR for the Therapy of Hematologic Malignancies

The Transferrin Receptor-Directed CAR for the Therapy of Hematologic Malignancies

As many patients ultimately relapse after chimeric antigen receptor (CAR) T-cell therapy, identification of alternative targets is currently being evaluated. Substantial research efforts are underway to develop new targets. The transferrin receptor (TfR) is prevalently expressed on rapidly prolifera...

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Bibliografiska uppgifter
Huvudupphovsmän: Zilong Guo, Yirui Zhang, Mingpeng Fu, Liang Zhao, Zhen Wang, Zhuoshuo Xu, Huifen Zhu, Xiaoli Lan, Guanxin Shen, Yong He, Ping Lei
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2021-03-01
Serie:Frontiers in Immunology
Ämnen:
transferrin receptor
chimeric antigen receptor
alternative target
hematological malignancies
T-cell acute lymphoblastic leukemia
Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652924/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652924/full

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