AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

ABSTRACT Cytosolic DNAs derived from retrotransposons serve as pathogen-associated molecular patterns for pattern recognition receptors (PRRs) that stimulate the induction of interferons (IFNs) and other cytokines, leading to autoimmune disease. Cyclic GMP-AMP synthase is one PRR that senses retrotr...

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Bibliographic Details
Main Authors: Yuki Nakaya, Jingtao Lilue, Spyridon Stavrou, Eileen A. Moran, Susan R. Ross
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
ALR
Aim2
Trex1
endogenous retrovirus
retrotransposon
self DNA
Online Access:https://journals.asm.org/doi/10.1128/mBio.00944-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00944-17

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