Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression

Abstract Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of phagocytes, and protects from pathogen...

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Main Authors: Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Neuroinflammation
Subjects:
Complement
Inflammation
Alzheimer’s disease
C5aR1
C5a
Disease-associated microglia
Online Access:https://doi.org/10.1186/s12974-022-02539-2

Internet

https://doi.org/10.1186/s12974-022-02539-2

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