Diversity and Complexity of Internally Deleted Viral Genomes in Influenza A Virus Subpopulations with Enhanced Interferon-Inducing Phenotypes

Diversity and Complexity of Internally Deleted Viral Genomes in Influenza A Virus Subpopulations with Enhanced Interferon-Inducing Phenotypes

Influenza A virus (IAV) populations harbor large subpopulations of defective-interfering particles characterized by internally deleted viral genomes. These internally deleted genomes have demonstrated the ability to suppress infectivity and boost innate immunity, rendering them promising for therape...

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Bibliographic Details
Main Authors: Amir Ghorbani, John M. Ngunjiri, Gloria Rendon, Christopher B. Brooke, Scott P. Kenney, Chang-Won Lee
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
influenza
subpopulations
interferon
defective genomes
NS1 truncation
Online Access:https://www.mdpi.com/1999-4915/15/10/2107

Internet

https://www.mdpi.com/1999-4915/15/10/2107

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