Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously quantify hesperidin and naringenin in microsamples (100 µL) of murine plasma after intragastric administration of single pure flavonoids and a mixture. The optimi...

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Bibliographic Details
Main Authors: Jesús Alfredo Araujo-León, Rolffy Ortiz-Andrade, Rivelino Armando Vera-Sánchez, Julio Enrique Oney-Montalvo, Tania Isolina Coral-Martínez, Zulema Cantillo-Ciau
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
ESI
flavonoid
optimization
pharmacokinetic
validation
QqQ
Online Access:https://www.mdpi.com/1420-3049/25/18/4241

Internet

https://www.mdpi.com/1420-3049/25/18/4241

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