Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor

Abstract The sigma-1 receptor (σ1R) is a non-opioid membrane receptor, which responds to a diverse array of synthetic ligands to exert various pharmacological effects. Meanwhile, candidates for endogenous ligands of σ1R have also been identified. However, how endogenous ligands bind to σ1R remains u...

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Bibliographic Details
Main Authors: Chunting Fu, Yang Xiao, Xiaoming Zhou, Ziyi Sun
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-49894-7