Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor
Abstract The sigma-1 receptor (σ1R) is a non-opioid membrane receptor, which responds to a diverse array of synthetic ligands to exert various pharmacological effects. Meanwhile, candidates for endogenous ligands of σ1R have also been identified. However, how endogenous ligands bind to σ1R remains u...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-49894-7 |