Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Abstract Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a promising approach to ameliorate migraine pai...

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Bibliographic Details
Main Authors: Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen, Rashid Giniatullin
Format: Article
Language:English
Published: BMC 2023-04-01
Series:The Journal of Headache and Pain
Subjects:
Headache
Anandamide
Neuronal firing
2-arachidonoylglycerol
Online Access:https://doi.org/10.1186/s10194-023-01568-3

Internet

https://doi.org/10.1186/s10194-023-01568-3

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