Epigenetic regulation in opioid induced hyperalgesia
About 25 million American adults experience pain daily and one of the most commonly prescribed drugs to treat pain are opioids. Prolonged opioid usage and dose escalations can cause a paradoxical response where patients experience enhanced pain sensitivity. This opioid induced hyperalgesia (OIH) is...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | Neurobiology of Pain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X23000338 |
| _version_ | 1797405386491297792 |
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| author | Deepa Reddy Jason R. Wickman Seena K. Ajit |
| author_facet | Deepa Reddy Jason R. Wickman Seena K. Ajit |
| author_sort | Deepa Reddy |
| collection | DOAJ |
| description | About 25 million American adults experience pain daily and one of the most commonly prescribed drugs to treat pain are opioids. Prolonged opioid usage and dose escalations can cause a paradoxical response where patients experience enhanced pain sensitivity. This opioid induced hyperalgesia (OIH) is a major hurdle when treating pain in the clinic because its underlying mechanisms are still not fully understood. OIH is also commonly overlooked and lacks guidelines to prevent its onset. Research on pain disorders and opioid usage have recognized potential epigenetic drivers of disease including DNA methylation, histone modifications, miRNA regulation, but their involvement in OIH has not been well studied. This article discusses epigenetic changes that may contribute to pathogenesis, with an emphasis on miRNA alterations in OIH. There is a crucial gap in knowledge including how multiple epigenetic modulators contribute to OIH. Elucidating the epigenetic changes underlying OIH and the crosstalk among these mechanisms could lead to the development of novel targets for the prevention and treatment of this painful phenomena. |
| first_indexed | 2024-03-09T03:09:24Z |
| format | Article |
| id | doaj.art-d267bae0577f4c91950b230bac2d3d94 |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-03-09T03:09:24Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-d267bae0577f4c91950b230bac2d3d942023-12-04T05:23:45ZengElsevierNeurobiology of Pain2452-073X2023-08-0114100146Epigenetic regulation in opioid induced hyperalgesiaDeepa Reddy0Jason R. Wickman1Seena K. Ajit2Department of Pharmacology & Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USADepartment of Pharmacology & Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USACorresponding author at: Pharmacology & Physiology, Drexel University College of Medicine, 245 North 15th Street, Mail Stop 488, Room 8223, Philadelphia, PA 19102.; Department of Pharmacology & Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USAAbout 25 million American adults experience pain daily and one of the most commonly prescribed drugs to treat pain are opioids. Prolonged opioid usage and dose escalations can cause a paradoxical response where patients experience enhanced pain sensitivity. This opioid induced hyperalgesia (OIH) is a major hurdle when treating pain in the clinic because its underlying mechanisms are still not fully understood. OIH is also commonly overlooked and lacks guidelines to prevent its onset. Research on pain disorders and opioid usage have recognized potential epigenetic drivers of disease including DNA methylation, histone modifications, miRNA regulation, but their involvement in OIH has not been well studied. This article discusses epigenetic changes that may contribute to pathogenesis, with an emphasis on miRNA alterations in OIH. There is a crucial gap in knowledge including how multiple epigenetic modulators contribute to OIH. Elucidating the epigenetic changes underlying OIH and the crosstalk among these mechanisms could lead to the development of novel targets for the prevention and treatment of this painful phenomena.http://www.sciencedirect.com/science/article/pii/S2452073X23000338Opioid induced hyperalgesiaPainMu opioid receptorEpigeneticsmicroRNAs |
| spellingShingle | Deepa Reddy Jason R. Wickman Seena K. Ajit Epigenetic regulation in opioid induced hyperalgesia Neurobiology of Pain Opioid induced hyperalgesia Pain Mu opioid receptor Epigenetics microRNAs |
| title | Epigenetic regulation in opioid induced hyperalgesia |
| title_full | Epigenetic regulation in opioid induced hyperalgesia |
| title_fullStr | Epigenetic regulation in opioid induced hyperalgesia |
| title_full_unstemmed | Epigenetic regulation in opioid induced hyperalgesia |
| title_short | Epigenetic regulation in opioid induced hyperalgesia |
| title_sort | epigenetic regulation in opioid induced hyperalgesia |
| topic | Opioid induced hyperalgesia Pain Mu opioid receptor Epigenetics microRNAs |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X23000338 |
| work_keys_str_mv | AT deepareddy epigeneticregulationinopioidinducedhyperalgesia AT jasonrwickman epigeneticregulationinopioidinducedhyperalgesia AT seenakajit epigeneticregulationinopioidinducedhyperalgesia |