An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

Background: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but is expensive and rarely available. The anticancer agent tamoxifen has synergistic anti-cryptococcal activity with amphotericin in vitro. It is off-patent, cheap, and widely available. We performed a trial to d...

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Bibliographic Details
Main Authors: Nguyen Thi Thuy Ngan, Nhat Thanh Hoang Le, Nguyen Ngo Vi Vi, Ninh Thi Thanh Van, Nguyen Thi Hoang Mai, Duong Van Anh, Phan Hai Trieu, Nguyen Phu Huong Lan, Nguyen Hoan Phu, Nguyen Van Vinh Chau, David G Lalloo, William Hope, Justin Beardsley, Nicholas J White, Ronald Geskus, Guy E Thwaites, Damian Krysan, Luong Thi Hue Tai, Evelyne Kestelyn, Tran Quang Binh, Le Quoc Hung, Nguyen Le Nhu Tung, Jeremy N Day
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
cryptococcus neoformans
cryptococcus gattii
HIV
randomised controlled trial
cryptococcal meningitis
Viet Nam
Online Access:https://elifesciences.org/articles/68929

Internet

https://elifesciences.org/articles/68929

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