Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail

Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail

Currently used hepatocyte cell systems for in vitro assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suit-ability of the validated in vivo Basel phenotyping cocktail (caffeine [CYP1A2], efavirenz [CYP2B6], losartan [CYP2C9],...

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Bibliographic Details
Main Authors: Benjamin Berger, Massimiliano Donzelli, Swarna Maseneni, Franziska Boess, Adrian Roth, Stephan Krähenbühl, Manuel Haschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
CYP induction
Liquid chromatography tandem mass spectrometry
Cytochrome P450 (CYP)
Basel cocktail
3-dimensional spheroid primary human hepatocyte culture
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00443/full

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http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00443/full

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