The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus

The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus

Introduction/objectivesIn 2012, hypocomplementemia was included in the classification criteria of systemic lupus erythematosus (SLE). The suggested measurement of C3 or C4 often reflect disease activity poorly. Our objective was to establish an assay measuring C3dg, which is generated following comp...

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Bibliographic Details
Main Authors: Anne Troldborg, Lisbeth Jensen, Bent Deleuran, Kristian Stengaard-Pedersen, Steffen Thiel, Jens Christian Jensenius
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
complement system
complement activation
systemic lupus erythematosus
biomarker
diagnostics
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00581/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00581/full

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