Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes

Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes

Sphingolipids are important biological mediators both in health and disease. We investigated the vascular effects of enhanced sphingomyelinase (SMase) activity in a mouse model of type 2 diabetes mellitus (T2DM) to gain an understanding of the signaling pathways involved. Myography was used to measu...

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Bibliographic Details
Main Authors: Éva Ruisanchez, Anna Janovicz, Rita Cecília Panta, Levente Kiss, Adrienn Párkányi, Zsuzsa Straky, Dávid Korda, Károly Liliom, Gábor Tigyi, Zoltán Benyó
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
sphingolipids
sphingomyelinase
vasorelaxation
endothelial nitric oxide synthase
type 2 diabetes
thromboxane prostanoid receptor
Online Access:https://www.mdpi.com/1422-0067/24/9/8375

Internet

https://www.mdpi.com/1422-0067/24/9/8375

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