Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells

Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells

Hypoxia, a hallmark characteristic of glioblastoma (GBM) induces changes in the transcriptome and the proteome of tumor cells. We discovered that hypoxic stress produces significant qualitative and quantitative changes in the protein content of secreted exosomes from GBM cells. Among the proteins fo...

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Bibliographic Details
Main Authors: Rajshekhar A. Kore, Jacob L. Edmondson, Samir V. Jenkins, Azemat Jamshidi-Parsian, Ruud P.M. Dings, Nathan S. Reyna, Robert J. Griffin
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Exosomes
Hypoxia
Glioblastoma
Transcriptome
Proteomics
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817302285

Internet

http://www.sciencedirect.com/science/article/pii/S2405580817302285

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