Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A V<sub>H</sub>H Domain

Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A V<sub>H</sub>H Domain

Interleukin-17 (IL-17) is a cytokine produced by the Th17 cells. It is involved in chronic inflammation in patients with autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and psoriasis. The antibodies targeting IL-17 and/or IL-17R are therapy tools...

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Bibliographic Details
Main Authors: Olga Kostareva, Arina Svoeglazova, Ilya Kolyadenko, Alexey Nikulin, Stanislav Evdokimov, Uliana Dzhus, Azat Gabdulkhakov, Svetlana Tishchenko
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin 17A in complex with V<sub>H</sub>H domain
netakimab
crystal structure
Online Access:https://www.mdpi.com/1422-0067/23/23/14904

Internet

https://www.mdpi.com/1422-0067/23/23/14904

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