Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology

Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology

ABSTRACT The conserved ESX-1 type VII secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum. ESX-1 is known to interact with infected macrophages, but its potential roles in regulating other host cells and immunop...

Full description

Bibliographic Details
Main Authors: Julia Lienard, Kristina Munke, Line Wulff, Clément Da Silva, Julien Vandamme, Katie Laschanzky, Thorsten Joeris, William Agace, Fredric Carlsson
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
mycobacterial pathogenesis
ESX-1 type VII secretion
host-pathogen interactions
immunopathology
neutrophils
monocytes
Online Access:https://journals.asm.org/doi/10.1128/mbio.02764-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02764-22

Similar Items