Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

Abstract Background Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have previously shown that NRAS is highly expressed selectively in basal-li...

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Bibliographic Details
Main Authors: Ze-Yi Zheng, Hanan Elsarraj, Jonathan T. Lei, Yan Hong, Meenakshi Anurag, Long Feng, Hilda Kennedy, Yichao Shen, Flora Lo, Zifan Zhao, Bing Zhang, Xiang H.-F. Zhang, Ossama W. Tawfik, Fariba Behbod, Eric C. Chang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Breast Cancer Research
Subjects:
Breast cancer
DCIS
Premalignancy
Invasion
Ras GTPase
Online Access:https://doi.org/10.1186/s13058-022-01565-5

Internet

https://doi.org/10.1186/s13058-022-01565-5

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