ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.

Bibliographic Details
Main Authors: Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36132-9

Internet

https://doi.org/10.1038/s41467-023-36132-9

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