ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.
Bibliographic Details
| Main Authors: |
Matteo Gentili,
Bingxu Liu,
Malvina Papanastasiou,
Deborah Dele-Oni,
Marc A. Schwartz,
Rebecca J. Carlson,
Aziz M. Al’Khafaji,
Karsten Krug,
Adam Brown,
John G. Doench,
Steven A. Carr,
Nir Hacohen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-36132-9
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