Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

Background: Fibrosis results in excessive buildup of extracellular matrix proteins along with abnormalities in structure and is partly derived by a process involving transforming growth factor β (TGF-β) called endothelial-to-mesenchymal transition (EndMT). We investigated whether the aldosterone rec...

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Bibliographic Details
Main Authors: Xiao Chen, Jiejie Cai, Xi Zhou, Lingzhi Chen, Yongsheng Gong, Zhan Gao, Huaiqin Zhang, Weijian Huang, Hao Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Spironolactone
Fibrosis
EndMT
TGF-β
Notch pathway
HUVEC
Online Access:http://www.karger.com/Article/FullText/374063

Internet

http://www.karger.com/Article/FullText/374063

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