The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A
<p>Abstract</p> <p>Accurate chromosome segregation during meiosis and mitosis is essential for the maintenance of genomic stability. Defects in the regulation of chromosome segregation during division predispose cells to undergo mitotic catastrophe or neoplastic transformation. Coh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2006-05-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/1/1/9 |
| _version_ | 1818146318354219008 |
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| author | Dai Wei Wang Xiaoxing |
| author_facet | Dai Wei Wang Xiaoxing |
| author_sort | Dai Wei |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Accurate chromosome segregation during meiosis and mitosis is essential for the maintenance of genomic stability. Defects in the regulation of chromosome segregation during division predispose cells to undergo mitotic catastrophe or neoplastic transformation. Cohesin, a molecular glue holding sister chromatids together, is removed from chromosomes in a stepwise fashion during mitosis and meiosis. Cohesin at centromeres but not on chromosome arm remains intact until anaphase onset during early mitosis and the initiation of anaphase II during meiosis. Several recent studies indicate that the activity of protein phosphatase 2A is essential for maintaining the integrity of centromeric cohesin. Shugoshin, a guardian for sister chromatid segregation, may cooperate with and/or mediate PP2A function by suppressing the phosphorylation status of centromeric proteins including cohesin.</p> |
| first_indexed | 2024-12-11T12:17:27Z |
| format | Article |
| id | doaj.art-d287126c0d5a4d4788c69892c4bc7c32 |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-12-11T12:17:27Z |
| publishDate | 2006-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-d287126c0d5a4d4788c69892c4bc7c322022-12-22T01:07:37ZengBMCCell Division1747-10282006-05-0111910.1186/1747-1028-1-9The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2ADai WeiWang Xiaoxing<p>Abstract</p> <p>Accurate chromosome segregation during meiosis and mitosis is essential for the maintenance of genomic stability. Defects in the regulation of chromosome segregation during division predispose cells to undergo mitotic catastrophe or neoplastic transformation. Cohesin, a molecular glue holding sister chromatids together, is removed from chromosomes in a stepwise fashion during mitosis and meiosis. Cohesin at centromeres but not on chromosome arm remains intact until anaphase onset during early mitosis and the initiation of anaphase II during meiosis. Several recent studies indicate that the activity of protein phosphatase 2A is essential for maintaining the integrity of centromeric cohesin. Shugoshin, a guardian for sister chromatid segregation, may cooperate with and/or mediate PP2A function by suppressing the phosphorylation status of centromeric proteins including cohesin.</p>http://www.celldiv.com/content/1/1/9 |
| spellingShingle | Dai Wei Wang Xiaoxing The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A Cell Division |
| title | The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A |
| title_full | The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A |
| title_fullStr | The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A |
| title_full_unstemmed | The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A |
| title_short | The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A |
| title_sort | yin and yang of centromeric cohesion of sister chromatids mitotic kinases meet protein phosphatase 2a |
| url | http://www.celldiv.com/content/1/1/9 |
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