Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy

Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy

Background Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including TNNI3, are reported to cause Ca2+ hypersensitivity in cardiomyocytes in overexpression models; however, the pa...

Full description

Bibliographic Details
Main Authors: Renjie Wang, Moyu Hasegawa, Hidehiro Suginobe, Chika Yoshihara, Yoichiro Ishii, Atsuko Ueyama, Kazutoshi Ueda, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, Jun Narita, Takuji Watanabe, Takuji Kawamura, Masaki Taira, Takayoshi Ueno, Shigeru Miyagawa, Hidekazu Ishida
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyocytes
diastolic dysfunction
iPSC
isogenic
motion analysis
restrictive cardiomyopathy
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.032375

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.032375

Similar Items