Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.

Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.

Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific...

Full description

Bibliographic Details
Main Authors: Xiaotun Zhang, Colm Morrissey, Shihua Sun, Melanie Ketchandji, Peter S Nelson, Lawrence D True, Funda Vakar-Lopez, Robert L Vessella, Stephen R Plymate
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3219707?pdf=render

Internet

http://europepmc.org/articles/PMC3219707?pdf=render

Similar Items