The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse established NASH is unknown. Methods: N-acetylgalactosa...

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Bibliographic Details
Main Authors: Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F. Kramer, George Ho, Carlos Rodriguez, Krishna Yekkala, Chidozie Amuzie, Russell Bialecki, Lisa Norquay, Andrea R. Nawrocki, Mark Erion, Alessandro Pocai, Orian S. Shirihai, Marc Liesa
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Molecular Metabolism
Subjects:
NASH
Mitochondria
ISR
Drp1
Oma1
Atf4
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001351

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822001351

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