Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding

Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding

Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or 2-fluorocinnamyl moieties connected to 2-fluoropyridylpiperazines. The three-step sy...

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Bibliographic Details
Main Authors: Ivana I. Jevtić, Thu Hang Lai, Jelena Z. Penjišević, Sladjana Dukić-Stefanović, Deana B. Andrić, Peter Brust, Sladjana V. Kostić-Rajačić, Rodrigo Teodoro
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
MAO-B
positron emission tomography
piperazine
cinnamic acid
Online Access:https://www.mdpi.com/1420-3049/25/21/4941

Internet

https://www.mdpi.com/1420-3049/25/21/4941

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