DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing

Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA lesions. Treatment with UV induced phosphorylation o...

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Bibliographic Details
Main Authors: Philamer C. Calses, Kiranjit K. Dhillon, Nyka Tucker, Yong Chi, Jen-wei Huang, Masaoki Kawasumi, Paul Nghiem, Yemin Wang, Bruce E. Clurman, Celine Jacquemont, Philip R. Gafken, Kaoru Sugasawa, Masafumi Saijo, Toshiyasu Taniguchi
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
DGCR8
Drosha
UV radiation
transcription-coupled nucleotide excision repair
JNK
microRNA
DNA repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303388

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http://www.sciencedirect.com/science/article/pii/S2211124717303388

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