PQM-1 controls hypoxic survival via regulation of lipid metabolism
Animals respond to hypoxic stress by adjusting metabolic processes to balance survival and reproduction. Here the authors identify the transcription factor PQM-1 as a metabolic regulator that balances hypoxic lipid and carbohydrate metabolism in C. elegans to limit somatic integrity and promote prog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18369-w |
| _version_ | 1818845611876679680 |
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| author | Thomas Heimbucher Julian Hog Piyush Gupta Coleen T. Murphy |
| author_facet | Thomas Heimbucher Julian Hog Piyush Gupta Coleen T. Murphy |
| author_sort | Thomas Heimbucher |
| collection | DOAJ |
| description | Animals respond to hypoxic stress by adjusting metabolic processes to balance survival and reproduction. Here the authors identify the transcription factor PQM-1 as a metabolic regulator that balances hypoxic lipid and carbohydrate metabolism in C. elegans to limit somatic integrity and promote progeny survival. |
| first_indexed | 2024-12-19T05:32:25Z |
| format | Article |
| id | doaj.art-d2a1b5b87ca647a2a6c7a8ab4ed3126e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:32:25Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d2a1b5b87ca647a2a6c7a8ab4ed3126e2022-12-21T20:34:13ZengNature PortfolioNature Communications2041-17232020-10-0111111510.1038/s41467-020-18369-wPQM-1 controls hypoxic survival via regulation of lipid metabolismThomas Heimbucher0Julian Hog1Piyush Gupta2Coleen T. Murphy3Lewis-Sigler Institute for Integrative Genomics, Princeton UniversityBioinformatics and Molecular Genetics, Faculty of Biology, University of FreiburgBioinformatics and Molecular Genetics, Faculty of Biology, University of FreiburgLewis-Sigler Institute for Integrative Genomics, Princeton UniversityAnimals respond to hypoxic stress by adjusting metabolic processes to balance survival and reproduction. Here the authors identify the transcription factor PQM-1 as a metabolic regulator that balances hypoxic lipid and carbohydrate metabolism in C. elegans to limit somatic integrity and promote progeny survival.https://doi.org/10.1038/s41467-020-18369-w |
| spellingShingle | Thomas Heimbucher Julian Hog Piyush Gupta Coleen T. Murphy PQM-1 controls hypoxic survival via regulation of lipid metabolism Nature Communications |
| title | PQM-1 controls hypoxic survival via regulation of lipid metabolism |
| title_full | PQM-1 controls hypoxic survival via regulation of lipid metabolism |
| title_fullStr | PQM-1 controls hypoxic survival via regulation of lipid metabolism |
| title_full_unstemmed | PQM-1 controls hypoxic survival via regulation of lipid metabolism |
| title_short | PQM-1 controls hypoxic survival via regulation of lipid metabolism |
| title_sort | pqm 1 controls hypoxic survival via regulation of lipid metabolism |
| url | https://doi.org/10.1038/s41467-020-18369-w |
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