Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain

Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain

Cinnabarinic acid (CA) is a trace kynurenine metabolite, which activates both type-4 metabotropic glutamate (mGlu4) and arylic hydrocarbon (Ah) receptors. We examined the action of CA in models of inflammatory and neuropathic pain moving from the evidence that mGlu4 receptors are involved in the reg...

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Bibliographic Details
Main Authors: Serena Notartomaso, Serena Boccella, N. Antenucci, Flavia Ricciardi, Francesco Fazio, F. Liberatore, P. Scarselli, M. Scioli, Giada Mascio, V. Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Sabatino Maione, Livio Luongo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
analgesia
neuropathic pain
cinnabarinic acid
metabotropic glutamate receptor 4
inflammatory pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.892870/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.892870/full

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