Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy

Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy

The α-Gal epitope consisting of the terminal trisaccharide Galα1,3Galβ1,4GlcNAc exposed on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity reactions, in humans. This epitope is also called the xenotransplantation epitope because it is one of the main reasons for...

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Bibliografski detalji
Glavni autori: Arthur Hinterholzer, Jennifer Moises, Christof Regl, Sebastian Schwap, Erdmann Rapp, Christian G. Huber, Mario Schubert
Format: Članak
Jezik:English
Izdano: Taylor & Francis Group 2022-12-01
Serija:mAbs
Teme:
Galili epitope
α-Gal
NMR spectroscopy
monoclonal antibody
posttranslational modification
Online pristup:https://www.tandfonline.com/doi/10.1080/19420862.2022.2132977

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2132977

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