Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true

Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true

One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic...

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Bibliographic Details
Main Authors: Joseli Lannes-Vieira, Jaline Coutinho Silverio, Isabela Resende Pereira, Nathália Ferreira Vinagre, Cristiano Marcelo Espinola Carvalho, Cláudia Neto Paiva, Andréa Alice da Silva
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2009-07-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Chagas disease
Trypanosoma cruzi
cardiomyopathy
chemokine
chemokine receptors
cell adhesion molecules
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900029

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900029

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