Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true
One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900029 |
| _version_ | 1827847600226697216 |
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| author | Joseli Lannes-Vieira Jaline Coutinho Silverio Isabela Resende Pereira Nathália Ferreira Vinagre Cristiano Marcelo Espinola Carvalho Cláudia Neto Paiva Andréa Alice da Silva |
| author_facet | Joseli Lannes-Vieira Jaline Coutinho Silverio Isabela Resende Pereira Nathália Ferreira Vinagre Cristiano Marcelo Espinola Carvalho Cláudia Neto Paiva Andréa Alice da Silva |
| author_sort | Joseli Lannes-Vieira |
| collection | DOAJ |
| description | One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms leading to clinical heart afflictions is a prerequisite to developing new therapies that ameliorate inflammation and improve heart function without hampering parasite control. Here, we review recent data showing that distinct cell adhesion molecules, chemokines and chemokine receptors participate in anti-parasite immunity and/or detrimental leukocyte trafficking to the heart. Moreover, we offer evidence that CC-chemokine receptors may be attractive therapeutic targets aiming to regain homeostatic balance in parasite/host interaction thereby improving prognosis, supporting that it is becoming a non-phantasious proposal. |
| first_indexed | 2024-03-12T09:32:35Z |
| format | Article |
| id | doaj.art-d2a869643b40466ebb1b7cda0f8ca43c |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:32:35Z |
| publishDate | 2009-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-d2a869643b40466ebb1b7cda0f8ca43c2023-09-02T13:54:04ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-07-0110422623510.1590/S0074-02762009000900029Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come trueJoseli Lannes-VieiraJaline Coutinho SilverioIsabela Resende PereiraNathália Ferreira VinagreCristiano Marcelo Espinola CarvalhoCláudia Neto PaivaAndréa Alice da SilvaOne hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms leading to clinical heart afflictions is a prerequisite to developing new therapies that ameliorate inflammation and improve heart function without hampering parasite control. Here, we review recent data showing that distinct cell adhesion molecules, chemokines and chemokine receptors participate in anti-parasite immunity and/or detrimental leukocyte trafficking to the heart. Moreover, we offer evidence that CC-chemokine receptors may be attractive therapeutic targets aiming to regain homeostatic balance in parasite/host interaction thereby improving prognosis, supporting that it is becoming a non-phantasious proposal.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900029Chagas diseaseTrypanosoma cruzicardiomyopathychemokinechemokine receptorscell adhesion molecules |
| spellingShingle | Joseli Lannes-Vieira Jaline Coutinho Silverio Isabela Resende Pereira Nathália Ferreira Vinagre Cristiano Marcelo Espinola Carvalho Cláudia Neto Paiva Andréa Alice da Silva Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true Memorias do Instituto Oswaldo Cruz Chagas disease Trypanosoma cruzi cardiomyopathy chemokine chemokine receptors cell adhesion molecules |
| title | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true |
| title_full | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true |
| title_fullStr | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true |
| title_full_unstemmed | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true |
| title_short | Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true |
| title_sort | chronic trypanosoma cruzi elicited cardiomyopathy from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors how to make a dream come true |
| topic | Chagas disease Trypanosoma cruzi cardiomyopathy chemokine chemokine receptors cell adhesion molecules |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900029 |
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