Early T cell signalling is reversibly altered in PD-1+ T lymphocytes infiltrating human tumors.

Early T cell signalling is reversibly altered in PD-1+ T lymphocytes infiltrating human tumors.

To improve cancer immunotherapy, a better understanding of the weak efficiency of tumor-infiltrating T lymphocytes (TIL) is necessary. We have analyzed the functional state of human TIL immediately after resection of three types of tumors (NSCLC, melanoma and RCC). Several signalling pathways (calci...

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Bibliographic Details
Main Authors: Shu-Fang Wang, Stéphane Fouquet, Maxime Chapon, Hélène Salmon, Fabienne Regnier, Karine Labroquère, Cécile Badoual, Diane Damotte, Pierre Validire, Eve Maubec, Nicolas B Delongchamps, Aurélie Cazes, Laure Gibault, Marylène Garcette, Marie-Caroline Dieu-Nosjean, Marc Zerbib, Marie-Françoise Avril, Armelle Prévost-Blondel, Clotilde Randriamampita, Alain Trautmann, Nadège Bercovici
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3049782?pdf=render

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http://europepmc.org/articles/PMC3049782?pdf=render

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